In systems with several effectors, the results of dose-response (DR) experiments are usually assessed by checking them against two hypotheses: independent action (IA) and concentration addition (CA).Both are useful simplifications, but do not represent the only possible responses, and avoid to a large extent the analysis of the interactions that ar
One of the most critical safety issues concerning the transportation and the distribution of hazardous materials, is the possible occurrence of accidental fires affecting transport vessels, leading to the heat up and consequent failure with catastrophic effects.Therefore, since the early seventies, numerous field studies and laboratory scale tests
Abstract Background Phosphorylated phosphatidylinositol (PtdIns) lipids, produced and modified by PtdIns kinases and phosphatases, Wire Cutter are critical to the regulation of diverse cellular functions.The myotubularin PtdIns-phosphate phosphatases have been well characterized in yeast and especially animals, where multiple isoforms, both catalyt